AUSTRALIAN JOURNAL OF BIOMEDICAL RESEARCH
Review Article

Antimicrobial Resistance and Health Equity: Disproportionate Public Health Impacts in Resource-Limited Settings

Australian Journal of Biomedical Research, 2(2), 2026, aubm023, https://doi.org/10.63946/aubiomed/18957
Publication date: Jul 13, 2026
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ABSTRACT

Antimicrobial resistance (AMR) is one of the most pressing global public health threats, compromising the effectiveness of antimicrobial therapies and increasing the burden of infectious diseases worldwide. Although AMR affects all populations, its impacts are disproportionately concentrated in resource-limited settings where poverty, inadequate healthcare infrastructure, poor sanitation, and limited access to quality medicines increase vulnerability to resistant infections. This narrative review examines the relationship between AMR and health equity, highlighting how social and structural determinants shape exposure, susceptibility, and health outcomes among disadvantaged populations. Literature published between 2015 and 2026 was identified through searches of PubMed, Scopus, Web of Science, and Google Scholar and synthesized using a thematic narrative approach. The review identifies poverty, inadequate water, sanitation and hygiene infrastructure, low health literacy, weak healthcare systems, limited diagnostic capacity, workforce shortages, and insufficient surveillance systems as major contributors to AMR vulnerability. Women, children, rural populations, refugees, migrants, and displaced communities experience disproportionate burdens due to overlapping social and healthcare disadvantages. A One Health perspective further demonstrates how human, animal, and environmental factors interact to accelerate resistance transmission. Addressing AMR requires equity-centered strategies that strengthen primary healthcare, improve access to diagnostics and treatment, enhance surveillance systems, expand water and sanitation infrastructure, and promote community engagement. AMR is not merely a biological phenomenon but a manifestation of broader social and structural inequities requiring integrated and sustainable public health responses.

KEYWORDS

Antimicrobial Resistance Health Equity Global Health Low-Resource Settings Healthcare Access Health Disparities One Health

CITATION (Vancouver)

John AE, Adetola FT, Fasesin OO, Edoh RO, Bamidele FP, Oluwole FT. Antimicrobial Resistance and Health Equity: Disproportionate Public Health Impacts in Resource-Limited Settings. Australian Journal of Biomedical Research. 2026;2(2):aubm023. https://doi.org/10.63946/aubiomed/18957
APA
John, A. E., Adetola, F. T., Fasesin, O. O., Edoh, R. O., Bamidele, F. P., & Oluwole, F. T. (2026). Antimicrobial Resistance and Health Equity: Disproportionate Public Health Impacts in Resource-Limited Settings. Australian Journal of Biomedical Research, 2(2), aubm023. https://doi.org/10.63946/aubiomed/18957
Harvard
John, A. E., Adetola, F. T., Fasesin, O. O., Edoh, R. O., Bamidele, F. P., and Oluwole, F. T. (2026). Antimicrobial Resistance and Health Equity: Disproportionate Public Health Impacts in Resource-Limited Settings. Australian Journal of Biomedical Research, 2(2), aubm023. https://doi.org/10.63946/aubiomed/18957
AMA
John AE, Adetola FT, Fasesin OO, Edoh RO, Bamidele FP, Oluwole FT. Antimicrobial Resistance and Health Equity: Disproportionate Public Health Impacts in Resource-Limited Settings. Australian Journal of Biomedical Research. 2026;2(2), aubm023. https://doi.org/10.63946/aubiomed/18957
Chicago
John, Aneke Emeka, Funmilade Taiwo Adetola, Oluwatomilayo Oluwayinka Fasesin, Racheal Oghenenyerhovwo Edoh, Fiyinfoluwa Peace Bamidele, and Fabiyi Taiwo Oluwole. "Antimicrobial Resistance and Health Equity: Disproportionate Public Health Impacts in Resource-Limited Settings". Australian Journal of Biomedical Research 2026 2 no. 2 (2026): aubm023. https://doi.org/10.63946/aubiomed/18957
MLA
John, Aneke Emeka et al. "Antimicrobial Resistance and Health Equity: Disproportionate Public Health Impacts in Resource-Limited Settings". Australian Journal of Biomedical Research, vol. 2, no. 2, 2026, aubm023. https://doi.org/10.63946/aubiomed/18957

REFERENCES

  1. Ahmed SK, Hussein S, Qurbani K, Ibrahim RH, Fareeq A, Mahmood KA, et al. Antimicrobial resistance: Impacts, challenges, and future prospects. J Med Surg Public Health. 2024 Apr 1;2:100081. doi: 10.1016/j.glmedi.2024.100081
  2. El-Sayed SE, Messiha AA, Zafer M. Effective alternative strategies to combat challenges associated with MDR bacterial infections: Drug repurposing, role of artificial intelligence, and novel therapeutic options. J Infect Public Health. 2026 Feb 1;19(2):103058. doi: 10.1016/j.jiph.2025.103058
  3. World Health Organization. Antimicrobial resistance [Internet]. [cited 2026 Jun 13]. Available from: https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance
  4. Nazir A, Nazir A, Zuhair V, Aman S, Sadiq SUR, Hasan AH, et al. The Global Challenge of Antimicrobial Resistance: Mechanisms, Case Studies, and Mitigation Approaches. Health Sci Rep. 2025 Jul 23;8(7):e71077. doi: 10.1002/hsr2.71077 PubMed PMID: 40704322; PubMed Central PMCID: PMC12284435.
  5. Al-Khalaifah H, Rahman MH, Al-Surrayai T, Al-Dhumair A, Al-Hasan M. A One-Health Perspective of Antimicrobial Resistance (AMR): Human, Animals and Environmental Health. Life. 2025 Oct 12;15(10). doi: 10.3390/life15101598
  6. Baweja R, Singh M, Shukla S, Ravi R, Ahmad R, Mishra A. Antimicrobial resistance: Mechanism, causes, prevention and societal impact. The Microbe. 2025 Dec 1;9:100617. doi: 10.1016/j.microb.2025.100617
  7. Shutt A, Mukherjee AS, Nampoothiri V, Holmes A, Charani E. Social determinants of health and knowledge, attitude and practice studies on antimicrobial resistance—an evidence review and future direction. JAC Antimicrob Resist. 2025 Sep 4;7(5):dlaf141. doi: 10.1093/jacamr/dlaf141 PubMed PMID: 40917193; PubMed Central PMCID: PMC12409717.
  8. Murray CJL, Ikuta KS, Sharara F, Swetschinski L, Aguilar GR, Gray A, et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. The Lancet. 2022 Feb 12;399(10325):629–55. doi: 10.1016/S0140-6736(21)02724-0PubMed PMID: 35065702.
  9. Oliveira M, Antunes W, Mota S, Madureira-Carvalho Á, Dinis-Oliveira RJ, Silva DD da. An Overview of the Recent Advances in Antimicrobial Resistance. Microorganisms. 2024 Sep 20;12(9). doi: 10.3390/microorganisms12091920
  10. Hussain I, Rasool MF, Ullah J, Nafees M, Khan I, Kadirhaz M, et al. Exploring the association between multi-dimensional poverty and antibiotic resistance: findings from a mixed-methods study in Pakistan. Lancet Reg Health Southeast Asia. 2025 Aug 27;41:100656. doi: 10.1016/j.lansea.2025.100656 PubMed PMID: 40918591; PubMed Central PMCID: PMC12409374.
  11. Davis K, Limato R, Monga M, Egid B, Paul S, Okioma S, et al. Antimicrobial resistance, equity and justice in low- and middle-income countries: an intersectional critical interpretive synthesis. Nat Commun. 2025 Oct 13;16(1):9078. doi: 10.1038/s41467-025-64137-z
  12. Faturakhim F, Insani WN, Kautsar AP. Non-prescription antibiotic dispensing in community pharmacies in LMICs: a systematic review of prevalence, drivers, and policy implications. BMC Health Serv Res. 2026 Feb 20;26(1):410. doi: 10.1186/s12913-026-14194-x
  13. Bizuneh GKK, Addis NAA, Chanie GSS. Health literacy and antibiotic misuse among communities in Gondar City, Northwest Ethiopia: implications for antimicrobial resistance control. Front Trop Dis. 2026 Jun 11;7. doi: 10.3389/fitd.2026.1812248
  14. World Health Organization. WASH and antimicrobial resistance [Internet]. [cited 2026 Jun 13]. Available from: https://www.who.int/teams/environment-climate-change-and-health/water-sanitation-and-health/burden-of-disease/wash-and-antimicrobial-resistance
  15. Meradji S, Basher NS, Sassi A, Ibrahim NA, Idres T, Touati A. The Role of Water as a Reservoir for Antibiotic-Resistant Bacteria. Antibiotics. 2025 Jul 28;14(8). doi: 10.3390/antibiotics14080763
  16. Molan K, Zore A, Kregar Velikonja N. Health Literacy and Interventions on Antibiotics Use and AMR in Younger Generations in High-Income Countries—A Systematic Review. Antibiotics (Basel). 2025 Sep 17;14(9):940. doi: 10.3390/antibiotics14090940PubMed PMID: 41009918; PubMed Central PMCID: PMC12466577.
  17. Lawal O, Oyebamiji HO, Kelenna IJ, Chioma FJ, Oyefeso E, Adeyemi BI, et al. A Review on Usage of Digital Health Literacy to Combat Antibiotic Misuse and Misinformation in Nigeria: Review Article. J Pharma Insights Res. 2025 Apr 5;3(2):258–69. doi: 10.69613/dja1jc18
  18. Mendoza AMB, Maliñana SAA, Maravillas SID, Moniva KC, Jazul JP. Relationship of self-medication and antimicrobial resistance (AMR) in low- and middle-income countries (LMICs): a scoping review. J Public Health Emerg. 2025 Mar 25;9(0). doi: 10.21037/jphe-23-184
  19. Priyadarshini M, Gundimeda H. Analyzing the health impact of substandard housing environment and access to water, sanitation and hygiene in India. BMC Public Health. 2025 Nov 27;25:4181. doi: 10.1186/s12889-025-25028-6 PubMed PMID: 41310542; PubMed Central PMCID: PMC12659547.
  20. Weimann A, Oni T. A Systematised Review of the Health Impact of Urban Informal Settlements and Implications for Upgrading Interventions in South Africa, a Rapidly Urbanising Middle-Income Country. Int J Environ Res Public Health. 2019 Oct;16(19):3608. doi: 10.3390/ijerph16193608 PubMed PMID: 31561522; PubMed Central PMCID: PMC6801583.
  21. Elbehiry A, Marzouk E, Abalkhail A. Antimicrobial resistance at a turning point: microbial drivers, one health, and global futures. Front Microbiol. 2025 Nov 17;16. doi: 10.3389/fmicb.2025.1698809
  22. Skender K, Machowska A, Khare S, Singh V, Lundborg CS, Sharma M. Antibiotic prescribing practices, perceived constraints, and views on antimicrobial resistance among general and orthopedic surgeons in central India. Sci Rep. 2025 Jul 11;15:25099. doi: 10.1038/s41598-025-11173-w PubMed PMID: 40646238; PubMed Central PMCID: PMC12254354.
  23. Habboush Y, Guzman N. Antibiotic Resistance. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 [cited 2025 Oct 11]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK513277/ PubMed PMID: 30020649.
  24. Timbrook TT, Prinzi AM, Spivak ES. Diagnostic and antimicrobial stewardship workforce challenges: A crisis in combating antimicrobial resistance. Antimicrob Steward Healthc Epidemiol. 2023 Mar 29;3(1):e60. doi: 10.1017/ash.2023.147 PubMed PMID: 37113194; PubMed Central PMCID: PMC10127232.
  25. Itoh N, Okumura N, Akazawa-Kai N, Wachino C, Kuriki S, Kawabata T. Impact of an infectious disease specialist-led antimicrobial stewardship program and consultations during multiple antimicrobial shortages: A bayesian structural time-series analysis. PLoS One. 2026 Feb 2;21(2):e0340599. doi: 10.1371/journal.pone.0340599 PubMed PMID: 41628185; PubMed Central PMCID: PMC12863545.
  26. Kakkar AK, Shafiq N, Singh G, Ray P, Gautam V, Agarwal R, et al. Antimicrobial Stewardship Programs in Resource Constrained Environments: Understanding and Addressing the Need of the Systems. Front Public Health. 2020 Apr 28;8:140. doi: 10.3389/fpubh.2020.00140 PubMed PMID: 32411647; PubMed Central PMCID: PMC7198767.
  27. Otaigbe II. Mitigating inequitable access to appropriate antibiotics in low- and middle-income countries. JAC Antimicrob Resist. 2025 Apr 24;7(2):dlaf061. doi: 10.1093/jacamr/dlaf061 PubMed PMID: 40276025; PubMed Central PMCID: PMC12019631.
  28. Chabalenge B, Sahota T, Ermolina I, Tanna S. Substandard and falsified medicines in Africa: healthcare systems challenges, supply chain issues, regulatory challenges and strategies to increase access to quality medicines. Front Pharmacol. 16:1708784. doi: 10.3389/fphar.2025.1708784 PubMed PMID: 41341026; PubMed Central PMCID: PMC12668917.
  29. Hassen HK, Mekasha YT, Tegegne AA, Ozalp Y. A narrative review on problems in product quality, regulatory system constraints, and the concept of quality by design as a solution for quality assurance of African medicines. Front Med. 2024 Oct 3;11. doi: 10.3389/fmed.2024.1472495
  30. Mba IEE, Martins FT. Combating antimicrobial resistance in Africa: a strategic roadmap for surveillance, stewardship, and research. Front Cell Infect Microbiol. 2025 Dec 17;15. doi: 10.3389/fcimb.2025.1714021
  31. H OO, E.o O, C OT, S O. Data-Driven Machine Learning Techniques for the Prediction of Cholera Outbreak in West Africa. Int J Appl Nat Sci. 2023 Aug 25;1(1):09–21. doi: 10.61424/ijans.v1i1.5
  32. Tolera A, Firdisa D, Roba HS, Motuma A, Kitesa M, Abaerei AA. Barriers to healthcare data quality and recommendations in public health facilities in Dire Dawa city administration, eastern Ethiopia: a qualitative study. Front Digit Health. 2024 Mar 14;6:1261031. doi: 10.3389/fdgth.2024.1261031 PubMed PMID: 38550717; PubMed Central PMCID: PMC10972939.
  33. Centers for Disease Control and Prevention. Guidelines for Evaluating Surveillance Systems [Internet]. [cited 2026 Jun 13]. Available from: https://www.cdc.gov/mmwr/preview/mmwrhtml/00001769.htm
  34. Turja T. Overview of barriers to healthcare access: Medical deserts and individual sandboxes. J Family Med Prim Care. 2025 Jul;14(7):2608–12. doi: 10.4103/jfmpc.jfmpc_1903_24 PubMed PMID: 40814546; PubMed Central PMCID: PMC12349865.
  35. Getzzg. Strengthening healthcare systems to prevent antimicrobial resistance in LMICs: it is time to act. JOGH [Internet]. 2026 Mar 13 [cited 2026 Jun 13]. Available from: https://jogh.org/2026/jogh-16-03007/
  36. Okesanya OJ, Eshun G, Ukoaka BM, Manirambona E, Olabode ON, Adesola RO, et al. Water, sanitation, and hygiene (WASH) practices in Africa: exploring the effects on public health and sustainable development plans. Trop Med Health. 2024 Oct 9;52:68. doi: 10.1186/s41182-024-00614-3 PubMed PMID: 39385262; PubMed Central PMCID: PMC11463047.
  37. Elkhadry SW, Tahoon MAH. Health literacy and its association with antibiotic use and knowledge of antibiotic among Egyptian population: cross sectional study. BMC Public Health. 2024 Sep 16;24:2508. doi: 10.1186/s12889-024-19668-3 PubMed PMID: 39285352; PubMed Central PMCID: PMC11403963.
  38. The Royal College of Pathologists. The impact of workforce shortages on tackling antimicrobial resistance and healthcare-associated infections [Internet]. [cited 2026 Jun 13]. Available from: https://www.rcpath.org/profession/publications/college-bulletin/october-2023/the-impact-of-workforce-shortages-on-tackling-antimicrobial-resistance-and-healthcare-associated-infections.html
  39. Shukar S, Zahoor F, Hayat K, Saeed A, Gillani AH, Omer S, et al. Drug Shortage: Causes, Impact, and Mitigation Strategies. Front Pharmacol. 2021 Jul 9;12:693426. doi: 10.3389/fphar.2021.693426 PubMed PMID: 34305603; PubMed Central PMCID: PMC8299364.
  40. Reyes R, Ahn R, Thurber K, Burke TF. Urbanization and Infectious Diseases: General Principles, Historical Perspectives, and Contemporary Challenges. Challenges in Infectious Diseases. 2012 May 19;123–46. doi: 10.1007/978-1-4614-4496-1_4 PubMed Central PMCID: PMC7119955.
  41. Raju NP, Dhanorkar M, Singh P. The interplay between antimicrobial resistance genes and emerging contaminants in wastewater treatment plants: Key players in One Health. Ann Microbiol. 2025 Oct 7;75(1):28. doi: 10.1186/s13213-025-01814-w
  42. Salam MdA, Al-Amin MdY, Salam MT, Pawar JS, Akhter N, Rabaan AA, et al. Antimicrobial Resistance: A Growing Serious Threat for Global Public Health. Healthcare (Basel). 2023 Jul 5;11(13):1946. doi: 10.3390/healthcare11131946 PubMed PMID: 37444780; PubMed Central PMCID: PMC10340576.
  43. Monari C, Onorato L, Coppola N, Raviglione MCB, Gon G. Burden of Antimicrobial Resistance Among Women with Post-Partum Infections in Low-Middle Income Countries: A Systematic Review. J Epidemiol Glob Health. 2024 Apr 17;14(2):274–90. doi: 10.1007/s44197-024-00222-8 PubMed PMID: 38630391; PubMed Central PMCID: PMC11176113.
  44. Khetan M, Dhankhar R, Verma S, Arora S, Sangwan RK, Huda RK, et al. Barriers and facilitators for high-risk pregnancy care: a qualitative study on the perspective of pregnant women of rural Rajasthan. Reprod Health. 2026 Jan 19;23:43. doi: 10.1186/s12978-025-02233-5 PubMed PMID: 41555338; PubMed Central PMCID: PMC12903710.
  45. Emerging Pathogens and Resistance Mechanisms: Shaping Future Pediatric Antimicrobial Resistance. J Pure Appl Microbiol [Internet]. 2025 Mar 27 [cited 2026 Jun 13]. Available from: https://microbiologyjournal.org/emerging-pathogens-and-resistance-mechanisms-shaping-future-pediatric-antimicrobial-resistance/
  46. Galler JR, Bringas-Vega ML, Tang Q, Rabinowitz AG, Musa KI, Chai WJ, et al. Neurodevelopmental effects of childhood malnutrition: A neuroimaging perspective. NeuroImage. 2021 May 1;231:117828. doi: 10.1016/j.neuroimage.2021.117828
  47. Mesmar A, Mbaabu Limungi G, Elmadani M, Simon K, Hamad O, Tóth L, et al. Bridging healthcare disparities: a systematic review of healthcare access for disabled individuals in rural and urban areas. Front Health Serv. 5:1695320. doi: 10.3389/frhs.2025.1695320 PubMed PMID: 41341570; PubMed Central PMCID: PMC12669211.
  48. Cotugno S, De Vita E, Frallonardo L, Novara R, Papagni R, Asaduzzaman M, et al. Antimicrobial Resistance and Migration: Interrelation Between Two Hot Topics in Global Health. Ann Glob Health. 91(1):12. doi: 10.5334/aogh.4628 PubMed PMID: 40061583; PubMed Central PMCID: PMC11887466.
  49. Cantor D, Swartz J, Roberts B, Abbara A, Ager A, Bhutta ZA, et al. Understanding the health needs of internally displaced persons: A scoping review. J Migr Health. 2021 Jan 1;4:100071. doi: 10.1016/j.jmh.2021.100071
  50. Cotugno S, De Vita E, Frallonardo L, Novara R, Papagni R, Asaduzzaman M, et al. Antimicrobial Resistance and Migration: Interrelation Between Two Hot Topics in Global Health. Ann Glob Health. 2025 Mar 6;91(1). doi: 10.5334/aogh.4628
  51. Lawal O, Orenolu IO, Ajobiewe MA, Forson KAAM, Agu UF, Fidelix ME, et al. Hospital-Acquired Infections in the Age of Antimicrobial Resistance and Smart Surveillance. Aust J Biomed Res. 2025 Aug 16;1(1):aubm002. doi: 10.63946/aubiomed/16759
  52. Samreen, Ahmad I, Malak HA, Abulreesh HH. Environmental antimicrobial resistance and its drivers: a potential threat to public health. J Glob Antimicrob Resist. 2021 Dec 1;27:101–11. doi: 10.1016/j.jgar.2021.08.001
  53. Agu IC, Agu C, Obiobasi C, Mbachu CO, King R, Onwujekwe O, et al. A scoping review of intersectional drivers of antimicrobial use and misuse among consumers in sub-Saharan Africa. Discov Public Health. 2026 May 26;23(1):769. doi: 10.1186/s12982-026-02079-7
  54. Mahrous NN, Fallatah MM, Fitaihi RA, Aldahshan H, Alhhazmi AA, Al-Khaldi S, et al. Point-of-Care Diagnostic Technologies for Antimicrobial Resistance: Principles, Platforms, Clinical Impact, and Future Directions. Diagnostics. 2026 Apr 20;16(8). doi: 10.3390/diagnostics16081239
  55. Punch R, Azani R, Ellison C, Majury A, Hynds PD, Payne SJ, et al. The surveillance of antimicrobial resistance in wastewater from a one health perspective: A global scoping and temporal review (2014–2024). One Health. 2025 Dec 1;21:101139. doi: 10.1016/j.onehlt.2025.101139
  56. Salama RA, Abdel Kader RG, Wadid NA. Artificial intelligence in combating challenges in antimicrobial resistance: a narrative review. Infect Prev Pract. 2026 Jun 1;8(2):100522. doi: 10.1016/j.infpip.2026.100522

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