Keyword: Quality of Life
2 results found.
Original Article
Australian Journal of Biomedical Research, 2(3), 2026, aubm028, https://doi.org/10.63946/aubiomed/19640
ABSTRACT:
Background: Celiac disease is a chronic immune-mediated enteropathy caused by gluten exposure in genetically susceptible individuals, for which lifelong adherence to a gluten-free diet remains the only validated treatment. Data on dietary adherence and health-related quality of life in North African pediatric populations remain limited. This study aimed to assess GFD adherence, HRQoL, and factors associated with poor adherence among Algerian children with CD.
Methods: This prospective observational cohort study was conducted in the Pediatric Department B of the University Hospital Center of Oran, Algeria, between January 2022 and June 2024. Children aged 2–16 years with confirmed CD (2020 ESPGHAN diagnostic criteria) were consecutively enrolled and prospectively followed at approximately three-month intervals (mean follow-up 18 ± 6 months). GFD adherence was assessed through structured dietary interviews; nutritional status was evaluated clinically and by laboratory assays (hemoglobin, ferritin, vitamin D); HRQoL was measured using the PedsQL and PROMIS pediatric measures. Univariate and multivariable logistic regression were used to identify factors associated with poor adherence, with odds ratios and adjusted odds ratios (aORs) and their 95% confidence intervals.
Results: Of 130 children assessed, 100 were included (mean age, 8.7 ± 3.4 years); 38% were classified as adherent and 62% as non-adherent. Children subsequently classified as non- adherent had lower baseline global quality-of-life scores than adherent children (59.7 ± 12.8 versus 78.4 ± 9.6; p < 0.001). Anxiety scores were higher in the non-adherent group among 84 children with available scores (57.2 ± 9.3 versus 46.8 ± 7.8; p < 0.001). Limited access to gluten-free products (adjusted odds ratio, 4.34; 95% confidence interval, 2.00–9.40), economic difficulties (3.70; 1.80–7.60), and psychological stress (2.60; 1.20–5.40) were associated with non-adherence. Nutritional abnormalities were present at enrollment in 72% of children and were associated with lower baseline quality-of-life scores (p < 0.001).
Conclusions: GFD adherence is suboptimal among Algerian children with CD and is associated with socioeconomic and psychosocial barriers and reduced HRQoL. Multidisciplinary management addressing nutritional, socioeconomic, and psychological factors is warranted. Given the observational design, the associations identified should not be interpreted as causal; larger multicenter longitudinal studies are needed to confirm these findings.
Methods: This prospective observational cohort study was conducted in the Pediatric Department B of the University Hospital Center of Oran, Algeria, between January 2022 and June 2024. Children aged 2–16 years with confirmed CD (2020 ESPGHAN diagnostic criteria) were consecutively enrolled and prospectively followed at approximately three-month intervals (mean follow-up 18 ± 6 months). GFD adherence was assessed through structured dietary interviews; nutritional status was evaluated clinically and by laboratory assays (hemoglobin, ferritin, vitamin D); HRQoL was measured using the PedsQL and PROMIS pediatric measures. Univariate and multivariable logistic regression were used to identify factors associated with poor adherence, with odds ratios and adjusted odds ratios (aORs) and their 95% confidence intervals.
Results: Of 130 children assessed, 100 were included (mean age, 8.7 ± 3.4 years); 38% were classified as adherent and 62% as non-adherent. Children subsequently classified as non- adherent had lower baseline global quality-of-life scores than adherent children (59.7 ± 12.8 versus 78.4 ± 9.6; p < 0.001). Anxiety scores were higher in the non-adherent group among 84 children with available scores (57.2 ± 9.3 versus 46.8 ± 7.8; p < 0.001). Limited access to gluten-free products (adjusted odds ratio, 4.34; 95% confidence interval, 2.00–9.40), economic difficulties (3.70; 1.80–7.60), and psychological stress (2.60; 1.20–5.40) were associated with non-adherence. Nutritional abnormalities were present at enrollment in 72% of children and were associated with lower baseline quality-of-life scores (p < 0.001).
Conclusions: GFD adherence is suboptimal among Algerian children with CD and is associated with socioeconomic and psychosocial barriers and reduced HRQoL. Multidisciplinary management addressing nutritional, socioeconomic, and psychological factors is warranted. Given the observational design, the associations identified should not be interpreted as causal; larger multicenter longitudinal studies are needed to confirm these findings.
Original Article
Australian Journal of Biomedical Research, 2(1), 2026, aubm013, https://doi.org/10.63946/aubiomed/17744
ABSTRACT:
Lower limb amputation is a major public health challenge that significantly impacts the lives of affected individuals, their relatives, healthcare systems, and society at large. Road traffic accidents (RTAs) are responsible for a significant percentage of the cases of lower limb amputations. The aim of this research is to analyze the existing literature to determine the prevalence of lower limb amputations resulting from severe lower extremity injuries caused by RTAs, as well as to examine the impact that these amputations have on quality of life (QoL) and psychological consequences.
A thorough literature search was carried out across three databases (PubMed, ScienceDirect, and Google Scholar), and a total of six publications were included in this review. The pooled effect was evaluated in Comprehensive Meta-Analysis (CMA) software, employing a random effect model. Based on our analysis, the pooled prevalence of lower limb amputations as a result of RTA was 43.2%. Out of the six studies that were considered for inclusion in this review, only three of them reported on results that were related to psychological outcomes and quality of life. It is necessary to have rehabilitation programs that are all-encompassing and address both the physical and psychological components.
A thorough literature search was carried out across three databases (PubMed, ScienceDirect, and Google Scholar), and a total of six publications were included in this review. The pooled effect was evaluated in Comprehensive Meta-Analysis (CMA) software, employing a random effect model. Based on our analysis, the pooled prevalence of lower limb amputations as a result of RTA was 43.2%. Out of the six studies that were considered for inclusion in this review, only three of them reported on results that were related to psychological outcomes and quality of life. It is necessary to have rehabilitation programs that are all-encompassing and address both the physical and psychological components.